gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The CAR-NK cells recognize TROP2, not CD122; they kill TROP2-positive tumor cells via perforin/granzyme. CD122 (IL-2Rβ) mediates IL-15 survival signaling for the NK cells and is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
autocrine IL-15 signaling on engineered NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05922930
disease_id_num_tar_ref
4873
drug_id_num_tar_ref
13136