gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR-NK cells kill TROP2-positive tumor cells via perforin/granzyme after CAR engagement. CD132 is not the CAR target; it is used for IL-15 signaling to support NK survival/proliferation, so CD132-expressing cells are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
autocrine IL-15 signaling on engineered NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05922930
disease_id_num_tar_ref
4873
drug_id_num_tar_ref
13136