gene_symbol
PRAME
hgnc_id
HGNC:9336
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native, MHC-restricted TCRs on the infused multiTAA-specific CD4+/CD8+ T cells recognize PRAME-derived peptides presented on HLA and directly lyse target cells via perforin/granzyme (with supportive cytokine-mediated effects).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC-restricted TCR recognition of peptide epitopes; class I and II depending on clone
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06549751
disease_id_num_tar_ref
427
drug_id_num_tar_ref
1206