gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti‑CD38 ADC binds CD38, is internalized, and releases an MMAF/auristatin payload that inhibits tubulin polymerization, causing G2/M arrest and apoptosis; Fc interactions can also induce ADCC/CDC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface glycoprotein ectoenzyme (NADase/cyclase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05565807
disease_id_num_tar_ref
4879
drug_id_num_tar_ref
13148