gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
STI-6129 targets CD38, is internalized, and releases an MMAF/duostatin payload that binds the vinca site on beta-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis; ADCC/CDC may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
target of auristatin/MMAF payload; inhibition of tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05565807
disease_id_num_tar_ref
4879
drug_id_num_tar_ref
13148