gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells, opsonizing them for Fcγ receptor–mediated ADCC by NK/macrophages, activates complement (CDC) to lyse cells, and can trigger apoptosis via CD20 crosslinking.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type I anti-CD20 mAb; binds conformational epitope on the large extracellular loop to induce ADCC/CDC/apoptosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06255704
disease_id_num_tar_ref
4882
drug_id_num_tar_ref
13157