gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
EGFR-targeted ADC binds EGFR, is internalized, and releases MMAE that inhibits tubulin polymerization, leading to microtubule disruption, G2/M arrest, and apoptosis of EGFR-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor targeted by the ADC antibody (becotatug)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05751512
disease_id_num_tar_ref
4883
drug_id_num_tar_ref
13165