gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MRG003 binds EGFR, is internalized, and releases MMAE, which binds beta‑tubulin to disrupt microtubules and cause G2/M arrest and apoptosis. Beta‑tubulin expression alone does not confer killing without EGFR-mediated delivery.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular payload target of MMAE; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05751512
disease_id_num_tar_ref
4883
drug_id_num_tar_ref
13165