gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and engages immune effectors via its Fc to induce antibody‑dependent cellular cytotoxicity (ADCC) (and potentially complement-mediated lysis), killing EGFR+ cells; it also blocks EGFR signaling (antiproliferative).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular ligand-binding domain epitope; blocks ligand binding and dimerization; mediates ADCC via Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05751512
disease_id_num_tar_ref
4883
drug_id_num_tar_ref
13166