gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-HER3 antibody–drug conjugate binds HER3, is internalized, and releases the topoisomerase I inhibitor DXd via a cleavable linker, causing DNA damage–mediated cell death; released payload can also produce a bystander effect.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor targeted by the antibody; internalization enables DXd payload release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06298084
disease_id_num_tar_ref
4884
drug_id_num_tar_ref
13168