gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered CD8+ T cells recognize the patient-specific peptide–HLA class I complex via the introduced TCR and directly kill target cells through cytotoxic granule release (perforin/granzymes) and death-receptor pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Personalized multi-target TCR set; allele-restricted (e.g., HLA-A/B/C); epitope sequence varies by patient
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05447234
disease_id_num_tar_ref
4885
drug_id_num_tar_ref
13170