gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DS-2243a bridges NY-ESO-1/HLA-A2 on tumor cells with CD3ε on T cells, activating T cells to kill the antigen-positive tumor cells (perforin/granzyme-mediated lysis); CD3ε-expressing T cells are effectors, not targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor-CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06644755
disease_id_num_tar_ref
4891
drug_id_num_tar_ref
13189