gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax binds and inhibits BCL-2 (BH3 mimetic), releasing pro-apoptotic factors to activate BAX/BAK, causing mitochondrial outer membrane permeabilization, caspase activation, and apoptosis of BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the BH3-binding hydrophobic groove (BH3 mimetic)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06247540
disease_id_num_tar_ref
4901
drug_id_num_tar_ref
13214