gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused autologous T cells recognize MAGE-A4–derived peptides presented on MHC via native TCRs and directly lyse target cells through perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC-restricted TCR recognition of peptide epitopes; class I and II depending on clone
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06549751
disease_id_num_tar_ref
427
drug_id_num_tar_ref
1206