gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3+ T cells are engaged, not killed; glofitamab crosslinks CD3 on T cells to CD20 on B cells, activating T-cell cytotoxicity (perforin/granzyme) against CD20+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TCR–CD3 complex target; specific subunit not specified in trial materials
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05861050
disease_id_num_tar_ref
4911
drug_id_num_tar_ref
13240