gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab targets CD20 on B cells; its Fc engages Fcγ receptors on immune effectors to mediate ADCC/ADCP and induces direct apoptosis of CD20+ B cells. CD16b-expressing cells (e.g., neutrophils) act as effectors, not targets, and are not directly killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated effector engagement; enhanced binding via glycoengineered Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05861050
disease_id_num_tar_ref
4911
drug_id_num_tar_ref
13241