gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds B7-H3 on target cells, is internalized, and releases a topoisomerase-1 inhibitor that blocks DNA replication, leading to cell cycle arrest and apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen; ADC antibody binds and internalizes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06422520
disease_id_num_tar_ref
4913
drug_id_num_tar_ref
13246