gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds EGFR on the tumor cell, is internalized, and releases the topoisomerase I inhibitor brengitecan, causing DNA damage and apoptosis (with potential bystander killing via payload diffusion).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; HER family member targeted by the ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06471205
disease_id_num_tar_ref
4920
drug_id_num_tar_ref
13267