gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 on target cells and mediates Fc-dependent killing (ADCC by NK cells, ADCP by macrophages) and complement-dependent cytotoxicity (CDC); can also induce apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme; inhibits NADase/ADP-ribosyl cyclase activity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05913596
disease_id_num_tar_ref
4921
drug_id_num_tar_ref
13269