gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-mediated ADCC by immune effector cells (e.g., NK cells) against EGFR-expressing cells; signaling blockade is mainly cytostatic, with radiosensitization enhancing kill with radiation.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III), blocking ligand binding and receptor dimerization; IgG1 Fc enables ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06676722
disease_id_num_tar_ref
4932
drug_id_num_tar_ref
13289