gene_symbol
CCR8
hgnc_id
HGNC:1609
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binding to CCR8 flags CCR8+ Tregs for Fc-mediated clearance, inducing ADCC/ADCP (and possibly CDC) by effector cells, leading to depletion of CCR8-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPCR on tumor-infiltrating Tregs; blocks CCL1–CCR8 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06387628
disease_id_num_tar_ref
4938
drug_id_num_tar_ref
13309