gene_symbol
CCR4
hgnc_id
HGNC:1605
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CCR4 IgG1 binds CCR4 on target cells and engages Fcγ receptors on NK cells to trigger ADCC, depleting CCR4+ cells (with possible contribution from ADCP/CDC).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPCR on malignant T cells and regulatory T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07003100
disease_id_num_tar_ref
4939
drug_id_num_tar_ref
13313