gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The EGFR/HER3-targeted ADC binds HER3 on tumor cells, is internalized, and releases a topoisomerase I inhibitor (brengitecan) that causes DNA damage leading to cell death.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface ErbB family receptor (kinase-impaired); bispecific ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06006169
disease_id_num_tar_ref
4940
drug_id_num_tar_ref
13314