gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-engineered gamma-delta T cells bind GPC3 on target cells, receive CD3z/CD28/4-1BB signaling, and kill GPC3+ cells via MHC-independent cytotoxicity (perforin/granzyme and Fas/FasL-mediated apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored, cell-surface heparan sulfate proteoglycan; tumor-associated antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06196294
disease_id_num_tar_ref
4944
drug_id_num_tar_ref
13323