gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and its afucosylated Fc engages FcγRIIIa on NK cells, triggering potent ADCC that induces apoptosis and depletion of IL-5Rα-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor; expressed on eosinophils/basophils
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06026202
disease_id_num_tar_ref
4948
drug_id_num_tar_ref
13343