gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils; its afucosylated Fc engages FcγRIIIa (CD16a) on NK cells to trigger ADCC, killing IL-5Rα+ eosinophils. CD16a-expressing cells act as effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCC; enhanced affinity due to afucosylation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06026202
disease_id_num_tar_ref
4948
drug_id_num_tar_ref
13343