gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Ofatumumab binds CD20 on B cells and induces complement-dependent cytotoxicity (MAC-mediated lysis) and Fc-mediated ADCC/antibody-dependent phagocytosis by NK cells and macrophages, directly depleting CD20+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface marker; binds a specific extracellular epitope on CD20
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06854341
disease_id_num_tar_ref
431
drug_id_num_tar_ref
1212