gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells and depletes them via Fc-mediated ADCC (NK cells), CDC (complement activation), ADCP (macrophages), and can also induce apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds an epitope in the large extracellular loop of CD20 on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05886036
disease_id_num_tar_ref
4964
drug_id_num_tar_ref
13381