gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
After HER2-targeted uptake, the ADC releases the DXd payload, which inhibits Top1–DNA complexes, causing DNA damage and apoptosis; cells are killed only if they receive the payload (via HER2-mediated internalization or bystander uptake).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DXd payload inhibits Top1 by stabilizing the Top1-DNA cleavage complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06409390
disease_id_num_tar_ref
435
drug_id_num_tar_ref
1226