gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Mosunetuzumab binds CD3 on T cells to activate them; the T cells then kill CD20+ B cells via immune synapse and perforin/granzyme release. CD3+ T cells are not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Subunit of the T-cell receptor/CD3 complex on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06090539
disease_id_num_tar_ref
4971
drug_id_num_tar_ref
13414