gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its IgG1 Fc engages FcγR+ effector cells (e.g., NK cells) to trigger ADCC and cell lysis; may also activate complement (CDC).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
extracellular domain (ligand-binding region)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06496178
disease_id_num_tar_ref
4999
drug_id_num_tar_ref
13494