gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds Trop-2 on tumor cells, is internalized, and releases SN-38, which inhibits topoisomerase I to cause DNA damage and apoptosis. Topoisomerase I expression alone does not direct targeting or selective killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
SN-38 payload stabilizes TOP1-DNA covalent complexes causing DNA breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06409390
disease_id_num_tar_ref
435
drug_id_num_tar_ref
1227