gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and triggers Fc-mediated killing (ADCC by NK cells, ADCP by macrophages, complement-dependent cytotoxicity) and can induce direct apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
type II transmembrane ectoenzyme
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06464991
disease_id_num_tar_ref
5010
drug_id_num_tar_ref
13541