gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Polatuzumab vedotin targets CD79b, is internalized, and releases MMAE that binds the vinca site on beta-tubulin to inhibit microtubules, causing G2/M arrest and apoptosis. Beta-tubulin itself is not the targeted antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload target; inhibits microtubule polymerization at the vinca site
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05498220
disease_id_num_tar_ref
5016
drug_id_num_tar_ref
13551