gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Bispecific T‑cell engager: binds CD3 on T cells and CD20 on B cells to form an immune synapse; activated T cells kill CD20+ B cells via perforin/granzyme. CD3+ T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor complex component; monovalent CD3-binding arm in 2:1 CD20:CD3 bispecific
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186648
disease_id_num_tar_ref
5018
drug_id_num_tar_ref
13559