gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD20 on B cells and kills via enhanced ADCC through Fc gamma RIIIa engagement, complement-dependent cytotoxicity (CDC), and direct caspase-independent cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20; glycoengineered afucosylated Fc enhances effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186648
disease_id_num_tar_ref
5018
drug_id_num_tar_ref
13560