gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc engages CD16a on NK cells to mediate ADCC (and can trigger CDC/direct death) against CD20+ B cells. CD16a-expressing cells are effector cells, not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated interaction; afucosylated Fc increases affinity, enhancing ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186648
disease_id_num_tar_ref
5018
drug_id_num_tar_ref
13560