gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
No direct cell killing via the soluble TNF-α target; the antibody neutralizes soluble TNF-α and blocks TNFR signaling. Cytotoxic effects (ADCC/CDC/apoptosis) occur only when binding membrane TNF-α, not the soluble form.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
soluble form
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06381518
disease_id_num_tar_ref
5020
drug_id_num_tar_ref
13570