gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells bind the neoantigen peptide–HLA complex on tumor cells, triggering cytotoxic T-cell activity and killing via perforin/granzyme-mediated apoptosis (and Fas–FasL pathways).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented by patient-specific HLA class I alleles as peptide–MHC (pMHC)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05292859
disease_id_num_tar_ref
5023
drug_id_num_tar_ref
13579