gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the neoantigen peptide–HLA-A complex via TCR/CD3, form an immune synapse, and induce apoptosis of target cells through perforin/granzyme release (and Fas–FasL).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-restricted pMHC target (e.g., HLA-A*02:01)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05292859
disease_id_num_tar_ref
5023
drug_id_num_tar_ref
13579