gene_symbol
HLA-B
hgnc_id
HGNC:4932
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-engineered T cells bind the specific neoantigen peptide–HLA-B complex, activate via TCR-CD3, and kill the target cell via perforin/granzyme-mediated cytolysis (and Fas/FasL apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-restricted pMHC target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05292859
disease_id_num_tar_ref
5023
drug_id_num_tar_ref
13579