gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Enfortumab vedotin targets Nectin-4 on the cell surface; after internalization, MMAE is released and binds beta‑tubulin (vinca site) to inhibit microtubule polymerization, causing G2/M arrest and apoptosis. Beta‑tubulin expression itself is not what selects cells for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload target; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06434350
disease_id_num_tar_ref
5026
drug_id_num_tar_ref
13585