gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds BCMA, is internalized, and releases MMAF that inhibits tubulin polymerization causing G2/M arrest and apoptosis; its afucosylated Fc also mediates ADCC/ADCP against BCMA+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain; afucosylated Fc enhances ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05986682
disease_id_num_tar_ref
5031
drug_id_num_tar_ref
13600