gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds BCMA (not tubulin) on target cells, is internalized, and releases MMAF, which binds the beta-tubulin vinca domain to block microtubule polymerization, causing G2/M arrest and apoptosis; tubulin itself is not the targeting antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAF payload binds beta-tubulin to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05986682
disease_id_num_tar_ref
5031
drug_id_num_tar_ref
13600