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gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on tumor cells and recruits FcγR-expressing immune effectors (e.g., NK cells) to induce antibody-dependent cell-mediated cytotoxicity (ADCC); may also activate complement. Signaling blockade is non-cytolytic.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain (ECD) subdomain IV epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06718335
disease_id_num_tar_ref
5034
drug_id_num_tar_ref
13608