gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Afucosylated IgG1 binds OX40 on activated T cells and engages Fcγ receptors on effector cells (e.g., NK cells), triggering enhanced ADCC (and phagocytosis) to deplete OX40+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor superfamily co-stimulatory receptor on activated T cells; binding blocks OX40–OX40L signaling and enables ADCC-mediated depletion of OX40+ cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05882877
disease_id_num_tar_ref
5040
drug_id_num_tar_ref
13627