gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD70 CAR-T cells bind CD70 on target cells and, upon CAR activation, kill via perforin/granzyme-mediated apoptosis (and Fas–FasL), lysing CD70-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TNFSF7; CD27 ligand; MHC-independent CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06010875
disease_id_num_tar_ref
5042
drug_id_num_tar_ref
13631