gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Ofatumumab binds CD20 on B cells and triggers complement-dependent cytotoxicity (CDC) and Fc-mediated ADCC by effector cells, leading to lysis and depletion of CD20+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane protein on B cells; ofatumumab binds a distinct epitope and induces CDC and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06486779
disease_id_num_tar_ref
5048
drug_id_num_tar_ref
13647