gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
GPC3-targeted CAR T cells recognize GPC3 on tumor cells and kill them via T-cell effector functions, primarily perforin/granzyme-mediated cytolysis and cytokine-driven apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPI-anchored heparan sulfate proteoglycan; tumor-associated antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06653023
disease_id_num_tar_ref
5059
drug_id_num_tar_ref
13675