gene_symbol
HIST1H3C
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes and expands H3K27M-specific CD8+ T cells; these CTLs recognize H3K27M peptides presented on MHC I of tumor cells and kill them via perforin/granzyme (and Fas–FasL) pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
On
hla_specific
Off
gated
Off
other_modifier
Lys27->Met (K27M) neoantigen peptide presented on MHC class I/II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04808245
disease_id_num_tar_ref
5075
drug_id_num_tar_ref
13722